SYSTEMIC LUPUS ERYTHEMATOSUS

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목차

Definition

Epidemiology

Pathobiology

Genetics

Environmental triggers

Immunologic trigger

Type I interferon

Autoantibodies

Immune complexes and complement

Clinical manifestations

Diagnostic criteria

The differential diagnosis

Lab findings

Autoantibodies’ frequency

Lab findings

treatment

prognosis

reference

본문내용

Definition
Systemic lupus erythematosus (SLE) - multisystemic autoimmune disease- involve the skin, joints, kidney, central nervous system, cardiovascular system, serosal membranes, hematologic and immune systems(highly heterogeneous : variable combinations of clinical features )-Immune complexes에 의한 inflammation : tissue damage.-Therapeutic approaches : immunosuppression.

Epidemiology
much more frequently in females than in males (F:M ratio = 8:1 to 9:1 in adults)
most cases are diagnosed between the ages of 15 and 44 years (children and women older than 55, the ratio is closer to 2:1 )
The prevalence of SLE : 약124 per 100,000 in the United States
The incidence of new cases : 1.8 to 7.6 per 100,000 per year.
African American 이 white population 보다 3~4배 많이 발생.
The severity of disease 역시 Hispanics 에서 whites보다 높게 나타난다.
Asians 또한 whites 보다 더 높은 유병율을 가진다.
최근의 소수 민족 lupus 연구 중, African Americans 과 Hispanics 에서 socioeconomic factors 가 prevalence와 severity를 높이는 데, major contributors 로 작용한다고 발표를 했다.

Pathobiology
Lupus pathogenesis
Genetic susceptibility
Environmental triggers
Microbial infection
Sunlight
drugs

참고 자료

Harrison p.1962~1975
Cecil p.2022~2031