[병리학] specific examples of apoptosis

등록일 2002.09.19 한글 (hwp) | 2페이지 | 가격 300원

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목차

A. Signaling by Tumor Necrosis Factor(TNF) Family ofReceptors
a. Fas-Fas ligand-mediated apoptosis
b. TNF-induced apoptosis
B. Cytotoxic T-Lymphocyte-Stimulated Apoptosis
C. Apoptosis After Growth Factor Deprivation
D. DNA Damage-Mediated Apoptosis

본문내용

A. Signaling by Tumor Necrosis Factor(TNF) Family of Receptors
:A subfamily of TNFR including Fas and TNFR1 exhibit homologous cytoplasmic 80-amino acid death recognition domains
a. Fas-Fas ligand-mediated apoptosis
:to be caused by cell surface receptor desiganated Fas(CD95)
1. A membrane-bound or soluble ligand(Fas ligand), produced by cells of the immune system, binds to Fas on T cells and activates a death program.
2. This system is important in that it eliminates activated lymphocytes from an immune reaction, thereby limiting the host response.
b. TNF-induced apoptosis
1. Activation of one of the TNF receptors(TNFR1) by the cytokine TNF can lead to apoptosis by inducing the association of the receptor with the adaptor protein TRADD.

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