ILD, 간질성 폐질환

소개글

간질성 폐질환, 특발성 폐섬유증에대한 자료 입니다.

목차

-Interstitial lung disease-
1. Pathogenesis
2. Initial assessment
-Idiopathic pulmonay fibrosis(IPF)-
1. 개요.
2. 임상양상
3. 진단
4. 치료
5. 예후

본문내용

-Interstitial lung disease-

• Interstitial lung disease(ILDs): a large number of conditions that involve the parenchyma of the lung- the alveoli, the alveolar epithelium, the capillary endothelium, and the spaces between these structures, as well as the perivascular and lymphatic tissues.
• considerable morbidity and mortality, and little consensus regarding the best management of most of them.
• major underlying histopathology에 따라 2 group으로 분류:
①inflammation and fibrosis ②granulomatous reaction
각 group은 원인이 알려진 질환과 알려지지 않은 질환으로 다시 분류
• m/c ILDs of unknown etiology: sarcoidosis, IPF, pulmonary fibrosis associated with CTDs.
Among the ILDs of known cause , the largest group comprises occupational and environmental exposures.

1. Pathogenesis
(1)Granulomatous lung disease: T lymphocytes, macrophages, epithelioid cells 등이 축적되어 granuloma를 형성, fibrosis로도 진행 가능. 심한 폐기능의 손상은 없음.
(2)Inflammation and fibrosis: alveolar wall 염증이 만성으로 진행하고 interstitium 및 vasculature로 번져서, 결국은 interstitial fibrosis를 초래하여 심한 폐기능 손상을 유발시킴.

참고 자료

1. HARRISON`s Principles of INTERNAL MEDICINE, 17th Edition