분자생물학에 대한 정리 (영어)

소개글

분자생물학에 대한 정리입니다. 영어로 정리하였으나 읽기 간단하며, 그림 설명이 아주 잘 정리되어 있어서 이해하기 쉽습니다.

목차

* RNA
- tRNA
- Ribosome
- Eukaryotic and prokaryotic mRNA
- mRNA structure
* Protein synthesis
- initiation
- elongation
- termination
* Using the genetic code
- Codon usage and wobbling
- Aminoacyl-tRNA synthetase
- Suppressor tRNA
- Variations in translation
* PROTEIN LOCALIZATION
- Protein translocation
- Chaperones in protein folding
- Signal sequences and Translocons 
- The Sec system
- Nuclear import and export
- Proteins degradation

본문내용

Messenger RNA (mRNA) is the intermediate that represents one strand of a gene coding for protein. Its coding region is related to the protein sequence by the triplet genetic code.
Transfer RNA (tRNA) is the intermediate in protein synthesis that interprets the genetic code. Each tRNA can be linked to an amino acid. The tRNA has an anticodon sequence that complementary to a triplet codon representing the amino acid.
Ribosomal RNA (rRNA) is a major component of the ribosome. Each of the two subunits of the ribosome has a major rRNA as well as many proteins.




Protein degradation
Ubiquitination targets proteins for degradation
Ubiquitin is added to proteins that are targeted for degradation by an apparatus consisting of three components.
Ubiquitin has a highly conserved sequence of 76 amino acids. It is linked via its COOH group to the ε NH2 group of a lysine residue in a target protein.
The ubiquitin cycle involves three activities. E1 is linked to ubiquitin. E3 binds to the substrate protein. E2 transfers ubiquitin from E1 to the substrate. Further cycles generate polyubiquitin.
Polyubiquitin is generated by successive cycles of adding ubiquitin.
The proteasome is a large machine that degrades ubiquitinated proteins
The proteasome is a large complex with an interior cavity that degrades cytosolic proteins previously marked by covalent addition of ubiquitin.
Protein degradation in the cytosol is catalyzed by the proteasome.
The 20S proteasome consists of four stacked rings each containing 7 subunits
Caps pass ubiquitinated proteins to the core for proteolysis.
The proteasome contains several different protease

참고 자료

www.ergito.com